ncRNA name | mmu-miR-146a |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Mus musculus |
Tissues/Cell_line | rat retinal endothelial cells (RECs); retinal capillary endothelial cell line Tr-iBRB |
Methods | miRNA RT-PCR Array, qRT-PCR, transfection, Western blot, immunofluorescence |
Expression pattern | up-regulated |
Functional description | It was demonstrated that the negative feedback regulation of miR-146 on NF-κB activation may function in Tr-iBRB endothelial cells, suggesting that miR-146 is a potential therapeutic target for the treatment of DR through its inhibition on NF-κB activation in RECs. |
PubMed ID | 21498619 |
Year | 2011 |
Title | MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats. |
Drug-related ncRNA | NO |
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